Record Display for the EPA National Library Catalog


OLS Field Name OLS Field Data
Main Title Cardiopulmonary Effects in Awake Rats Four and Six Months after Exposure to Methyl Isocyanate.
Author Tepper, J. S. ; Wiester, M. J. ; Costa, D. L. ; Watkinson, W. P. ; Weber, M. F. ;
CORP Author Northrop Services, Inc., Research Triangle Park, NC.;Health Effects Research Lab., Research Triangle Park, NC.
Year Published 1987
Report Number EPA-68-02-4032; EPA/600/J-87/371;
Stock Number PB88-224399
Additional Subjects Isocyanates ; Toxic diseases ; Respiratory diseases ; Pulmonary hypertension ; Laboratory rats ; Nitrogen organic compounds ; Exposure ; Electrocardiography ; Reprints ; Methyl isocyanate ; CAS 624-83-9 ; Respiratory function tests
Library Call Number Additional Info Location Last
NTIS  PB88-224399 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. 12/29/1988
Collation 12p
Cardiopulmonary function was assessed four and six months after Fischer-344 rats were exposed for 2 hr to 0, 3, or 10 ppm methyl isocyanate (MIC). Minute ventilation (VE) during CO2 challenge was increased in MIC-treated rats compared to controls suggesting a ventilation/perfusion inequality. An increase in maximum expiratory flow and a decrease in expiratory time indicated increased lung recoil. Evidence of pulmonary hypertension was observed in electrocardiograms (ECGs) and supported by postmortem analysis. Six months after exposure to MIC the increase in VE was no longer detectable. Forced expiratory flow-volume curves indicated persistent airway obstruction; however, no changes in inspiratory or expiratory resistance were evident. Decreased dynamic compliance and changes in two new measures of lung function, volume, and time at zero expiratory intrapleural pressure, suggest that MIC lung dysfunction also exhibited elements of a restrictive disease.