Record Display for the EPA National Library Catalog


OLS Field Name OLS Field Data
Main Title Pulmonary Function Studies in the Rat Addressing Concentration versus Time Relationships of Ozone (O3).
Author Costa, D. L. ; Hatch, G. E. ; Highfill, J. ; Stevens, M. A. ; Tepper, J. S. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC. ;Northrop Services, Inc., Research Triangle Park, NC.
Publisher Nov 88
Year Published 1988
Report Number EPA/600/D-88/256;
Stock Number PB89-129050
Additional Subjects Air pollution ; Ozone ; Toxicity ; Lung ; Respiratory function tests ; Exposure ; Laboratory animals ; Respiration ; Time ; Concentration(Composition) ;
Library Call Number Additional Info Location Last
NTIS  PB89-129050 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. 03/14/1989
Collation 13p
Recent data from human studies suggest that the current 1 hr National Ambient Air Quality Standard (NAAQS) for O3 may not be appropriate for exposures of several hours. Animal studies are being used to further investigate this issue. A polynomial model has been developed to depict lung injury from the interaction of O3 concentration (C) and exposure duration (T). The model was derived from lung fluid protein values in rats exposed in a matrix design to 0.1 to 0.8 ppm O3 for 2, 4, or 8 hrs. Airway dysfunction was correlated only at the highest CxT products. Rats, exposed to 0.5 or 0.8 ppm O3 for 2 or 7 hours with intermittent 8% CO2 to augment ventilation, were evaluated with static and dynamic lung function tests. Protein leakage into the airspace was also assessed. Although, the impact of T on O3 toxicity appeared to be C-dependent, loss of function was not necessarily linear. Collectively, studies provide a preliminary basis for the evaluation of duration of exposure on the pulmonary response to O3.