Record Display for the EPA National Library Catalog


OLS Field Name OLS Field Data
Main Title Using Ashford's General Model to Aid in the Understanding of a Pesticide's Neurotoxic Effect Through Pesticide-Drug Mixture Experiments.
Author Svendsgaard, D. J. ; Crofton, K. M. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC. ;North Carolina Univ. at Chapel Hill.
Year Published 1985
Report Number EPA/600/D-85/241;
Stock Number PB86-130028
Additional Subjects Pesticides ; Drugs ; Toxicology ; Models ; Synergism ; Neurotoxicity ; Ashfords models
Library Call Number Additional Info Location Last
NTIS  PB86-130028 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. 06/21/1988
Collation 15p
Ashford's 1981 paper in BIOMETRICS provides a framework for interpreting the joint action of mixtures of drugs. These concepts are applied to the situation in which the mechanism of three drugs are fairly well understood and mixtures of pesticides and drugs are studied to aid in the understanding of the mechanism of certain types of pesticides. Laboratory data is fit by nonlinear regression to models suggested by Ashford's paper. The conclusions drawn from fitting these models and the implication of the design of experiments for further studies are discussed.