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Main Title Molecular Mechanism of Mutagenesis: Results and Recommendations.
Author Sandhu, S. S. ; de Serres, F. J. ; Gopalan, H. N. B. ; Grant, W. F. ; Svendsgaard, D. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC. ;Research Triangle Inst., Research Triangle Park, NC. ;United Nations Environment Programme, Nairobi (Kenya). ;Macdonald Coll., Ste. Anne de Bellevue (Quebec). ;Institute of Experimental Botany, Prague (Czech Republic).
Publisher cNov 94
Year Published 1994
Report Number EPA/600/J-94/544;
Stock Number PB95-148060
Additional Subjects Mutagenesis ; Plants(Botany) ; Recommendations ; Bioassay ; Test methods ; Quality assurance ; Glycerol ; Sodium azides ; Laboratories ; Reprints ; Collaborative study ; IPCS(International Program on Chemical Safety) ; International Program on Chemical Safety ; AG(Azidoglycerol) ; MNU(Methyl nitrosourea) ; MH(Maleic hydrazide) ; EMS(Ethyl methane sulphonate) ; Arabidopsis ; Tradescantia ; Vicia faba
Library Call Number Additional Info Location Last
NTIS  PB95-148060 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 12p
In the first phase of a collaborative study for the International Program on Chemical Safety (IPCS), the World Health Organization, and the Environmental Program of the United Nations, four coded chemicals, i.e., Azidoglycerol (AG, 3-azido-1,2-propanediol), methyl nitrosourea (MNU), sodium azide (NaN3) and maleic hydrazide (MH) and ethyl methane sulphonate (EMS) as a positive control were tested in four plant bioassays, namely, the Arabidopsis embryo and chlorophyll mutation assay, the Tradescantia stamen hair assay (Trad-SH assay), the Tradescantia micronucleus assay (Trad-MCN), and the Vicia faba root tip assay. Seventeen laboratories from diverse regions of the world participated with four to six laboratories each using one plant assay testing all chemicals. Recommendations were made for minor changes in methodology and for initiating the second phase of this study.