Record Display for the EPA National Library Catalog


Main Title Endpoints of Spermatotoxicity in the Rat After Short Duration Exposures to Fourteen Reproductive Toxicants.
Author Linder, R. E. ; Strader, L. F. ; Slott, V. L. ; Suarez, J. D. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC. ;ManTech Environmental Technology, Inc., Research Triangle Park, NC.
Publisher c1992
Year Published 1992
Report Number EPA/600/J-93/107;
Stock Number PB93-175768
Additional Subjects Spermatozoa ; Reproduction(Biology) ; Toxicology ; Toxic substances ; In vivo analysis ; Structure-activity relationships ; Sperm motility ; Pathology ; Testis ; Epididymis ; Tables(Data) ; Reprints ;
Library Call Number Additional Info Location Last
NTIS  PB93-175768 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 17p
Multiple endpoints of spermatotoxicity in short in vivo tests were investigated in several chemicals which produce minimal to severe subchronic reproductive effects. Six chemicals (boric acid, dinoseb, 2,5-hexanedione, methoxychlor, metronidazole, ornidazole) produced spermatotoxicity. Chlordimeform was equivocal while pp'-DDT, n-hexane, and sodium chlorite were negative. Chemicals with known acute effects (benomyl, busulfan, EGME, nitrobenzene) elicited expected responses. Testicular histology, sperm head counts, cauda sperm counts, sperm morphology and velocity were the most sensitive endpoints, but histopathology was the most consistent indicator of damage. The data suggested that most chemicals which produce moderate sperm damage are detectable in a short duration test. Multiple endpoints enhanced interpretations, identified cellular targets, and provided insight on mechanisms. The responses often predicted effects seen in subchronic exposures. The short test could be used as a screen in SAR studies or to prioritize further evaluations. As a supplement, the short test could enhance the design and interpretation of longer tests.