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Main Title Metabolic engineering : principles and methodologies /
Author Stephanopoulos, G.,
Other Authors
Author Title of a Work
Aristidou, Aristos A.,
Nielsen, Jens H²iriis,
Publisher Academic Press,
Year Published 1998
OCLC Number 40342825
ISBN 0126662606; 9780126662603
Subjects Biochemical engineering ; Metabolism ; Biochemistry ; Biological control systems--Research ; Biomolecules--Analysis ; metabolism (biological concept) ; Metabolieten ; Moleculaire genetica ; Celbiologie ; Biosynthese ; Metabolismo ; Bioquimica ; Engenharia quimica ; Métabolisme ; Génie biochimique ; Biochimie ; Metabolic Engineering
Internet Access
Description Access URL
Table of contents
Publisher description
Library Call Number Additional Info Location Last
EJEM  TP248.3.S74 1998 OCSPP Chemical Library/Washington,DC 01/13/2001
Collation xxi, 725 pages : illustrations, graphs ; 23 cm
Some copies include statement about subsequent manufacture. For example, "Transferred to Digital Printing 2010."--Title page verso. Includes bibliographical references and index.
Contents Notes
(from table of contents) Preface -- List of symbols -- 1. The essence of metabolic engineering -- 2. Review of cellular metabolism -- 3. Comprehensive models for cellular reactions -- 4. Material balances and data consistency -- 5. Regulation of metabolic pathways -- 6. Examples of pathway manipulations : metabolic engineering in practice -- 7. Metabolic pathway synthesis -- 8. Metabolic flux analysis -- 9. Methods for the experimental determination of metabolic fluxes by isotope labeling -- 10. Applications of metabolic flux analysis -- 11. Metabolic control analysis -- 12. Analysis of structure of metabolic networks -- 13. Flux analysis of metabolic networks -- 14. Thermodynamics of cellular processes -- Glossary. "Metabolic engineering is an emerging, interdisciplinary field with applications to the production of chemicals, fuels, materials, and pharmaceuticals. The field's novelty lies in the integration of the techniques of molecular biology with the tools of mathematical analysis, to help elucidate metabolic flux control and rational selection of targets for genetic modification. By providing a rigorous description of cell physiology, metabolic engineering also facilitates functional genomics."--Back cover. "Its primary objective is to identify specific genetic and environmental manipulations that lead to enhancement of yield and productivity of biotechnological processes, or the overall improvement of cellular properties."--Back cover. "Key elements of the book include pathway integration and consideration of metabolic flux as a fundamental determinant of cell physiology. 'Metabolic Engineering' keeps mathematical complexity to a minimum, and provides sidebars as additional background on various mathematical operations. Computational tools for pathway analysis are described, and a glossary of biological terms facilitates use of the book by a broad audience of biochemists, molecular biologists, microbiologists, and biochemical/biomedical engineers. Key Features * Demonstrates metabolic engineering in action with numerous examples of pathway modification * Includes methods for identifying key enzymes in metabolic networks * Contains a comprehensive review of metabolic biochemistry * Discusses metabolic regulation at the gene, enzyme, operon, and cell levels * Explains concepts of stoichiometry, kinetics, and thermodynamics of metabolic pathways * Minimizes mathematical complexity * Links to a Web page to communicate updates of the software code and homework problems."--Back cover.