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RECORD NUMBER: 22 OF 24

OLS Field Name OLS Field Data
Main Title Species Comparison of Acute Inhalation Toxicity of Ozone and Phosgene.
Author Hatch, G. E. ; Slade, R. ; Stead, A. G. ; Graham, J. A. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC.
Year Published 1986
Report Number EPA/600/J-86/288;
Stock Number PB87-175063
Additional Subjects Air pollution ; Toxicity ; Ozone ; Phosgene ; Exposure ; Concentration(Composition) ; Chlorine organic compounds ; Inhalation ; Toxic substances
Holdings
Library Call Number Additional Info Location Last
Modified
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Status
NTIS  PB87-175063 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. 06/21/1988
Collation 13p
Abstract
A comparison of the concentration-response effects of inhaled ozone (O3) in different species of laboratory animals was made in order to better understand the influence of the choice of species in inhalation studies of this gas. The effect of 4 hour exposure to ozone (O3) at concentrations of 0.0, 0.2, 0.5, 1.0, and 2.0 ppm was determined in rabbits, guinea pigs, rats, hamsters and mice. Lavage fluid protein (LFP) accumulation 18 hr after exposure was used as the indicator of 03-induced pulmonary edema. All species had similar basal levels of LFP (250-350 ug/ml) when a volume of saline which approximated the total lung capacity was used for lavage of the collapsed lungs. Exponential dose-response curves were seen in all species except guinea pigs, which showed significant increases in LFP at low 03 concentrations (0.2 ppm) and a leveling off of response at the higher 03 levels. Other species usually showed significant elevations in LFP only at concentrations greater than 0.5 ppm. Recovery of lavage fluid as a percent of the amount of injected saline varied significantly between species, and between 03 concentrations; higher 03 levels causing lower recovery. The time course of LFP accumulation also appeared to vary according to the species.