Record Display for the EPA National Library Catalog


OLS Field Name OLS Field Data
Main Title Effects of Low Dosage of Stable Strontium on Serum Enzymes in Chronic Alcoholics.
Author Stara, J. F. ; Perras, J. ; Pivon, R. J. ; Koch, P. ; Nolan, J. T. ;
CORP Author Environmental Protection Agency, Cincinnati, OH. Environmental Criteria and Assessment Office. ;McGill Univ., Montreal (Quebec). ;La Maison Jean Lapointe, Montreal (Quebec).
Publisher c1986
Year Published 1986
Report Number EPA/600/D-89/032;
Stock Number PB89-223911
Additional Subjects Strontium compounds ; Alcoholism ; Enzymes ; Blood ; Mitochondria ; Dosage ; Glucosephosphate dehydrogenase ; Atomic absorption spectrophotometry ; GGTP
Library Call Number Additional Info Location Last
NTIS  PB89-223911 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. 12/18/1989
Collation 20p
The study shows the systemic effects of low dosage of stable Sr(2+) in relation to chronic ethanol abuse. In the current study, 6 chronic alcoholic patients were administered Sr carbonate (600-700 mg of Sr(2+) per day) for periods of 4-6 weeks, alternating with treatment-free (placebo) intervals. Serum GDH was determined using Koch's modification; GGTP was determined using standard methodology (Gilford Stasar III). Serum ethanol levels were determined using Alcohol Dipstick Methodology of Kapur and Israel. Serum Sr(2+) and Ca(2+) levels were determined by Atomic Absorption Spectrophotometry. In patients receiving Sr(2+), serum GDH levels were decreased 61-68% (range 44.9-88.6%) when compared to the control periods during the acute alcoholic episodes. The effects of Sr(2+) on serum GGTP levels varied in extent of decrease. The preliminary studies indicate that low dosage of Sr(2+) exerts a protective effect on mitochondrial function during acute alcoholic episodes.