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Main Title Health risk assessment of chemical mixtures
Author Stara, J. F. ; Patterson, J. ; Blackburn, K. ; Hertzberg, R. C. ; DeRosa, C. T.
Other Authors
Author Title of a Work
Stara, J. F.
CORP Author Environmental Protection Agency, Cincinnati, OH. Environmental Criteria and Assessment Office.
Publisher U.S. Environmental Protection Agency ;
Year Published 1989
Report Number EPA/600/D-89/028; PB89-222640
Stock Number PB89-222640
OCLC Number 26082443
Subjects Health risk assessment ; Environmental health ; Toxicity testing ; Chemicals--Risk assessment
Additional Subjects Hazardous materials ; Waste disposal ; Sites ; Water pollution ; Record of Decision ; First Remedial Action ; Superfund ; Chemical mixtures ; Health risk
Internet Access
Description Access URL
Library Call Number Additional Info Location Last
EJED  EPA-600/D-89/028 OCSPP Chemical Library/Washington,DC 06/26/1992
NTIS  PB89-222640 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation ii, 8 leaves ; 28 cm.
The implementation of Superfund requires a methodology for estimating health risk from multi-chemical contamination at ambient levels. Most often, the chemical composition of these mixtures is poorly characterized, exposure data are uncertain and toxicologic data on the known components of the mixture are limited. However, a potential human health hazard may exist and the U.S. EPA, state and local governments need to be able to assess the total hazard in order to make decisions on appropriate action. The paper describes a procedure for assessing the risks from chemical mixtures that includes options when different kinds of data are available. Good-quality information on the mixture of concern or a similar mixture should always be used. A less desirable, still useful approach, is to utilize data on components and their interactions. The quality of exposure and toxicity data must be determined and the uncertainties involved in each risk assessment must be thoroughly discussed. Water contamination is briefly discussed since it is of vital concern as the primary exposure medium for chemical mixtures. The methodology for estimating the human health risk from single chemicals, both carcinogens and systematic toxicants, is reviewed as it forms the basis for the assessment of mixtures.
"PB89-222640." "EPA/600/D-89/028."