Record Display for the EPA National Library Catalog


Main Title Evidence That Drug-Resistant Alloreactive T Cells May Contribute to Human Graft Rejection.
Author Stanford, W. L. ; Strauss, G. H. S. ; Finn., O. J. ;
CORP Author Duke Univ., Durham, NC.;National Institutes of Health, Bethesda, MD.;Environmental Protection Agency, Washington, DC.
Publisher c1990
Year Published 1990
Report Number PO1-AI19368; EPA/600/J-90/175;
Stock Number PB91-115774
Additional Subjects Humans ; Reprints ; T lymphocytes ; Homologous transplantation ; Graft rejection ; Immunosuppressive agents ; Drug resistance ; Azathioprine ; Autoradiography
Library Call Number Additional Info Location Last
NTIS  PB91-115774 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 6p
The objective of the study was to determine whether resistance to immunosuppressive drugs by transplant recipient's T cells could contribute to continued graft rejection, in spite of immunosuppressive therapy. The T cell lines used in the series of experiments were originally established from T cells that had infiltrated kidney or liver grafts and initiated rejections in patients receiving immunosuppressive drugs, including the purine analogue azathioprine (AZ). The authors have used a proliferation assay and the Strauss-Albertini test to analyze the T cell lines. Both assays use 6-thioguanine (6-TG), an amino derivative of AZ, as the selective agent to measure the resistance to AZ. (Copyright (c) 1990 by Williams and Wilkins.)