Record Display for the EPA National Library Catalog


Main Title Concept of Activity Profiles of Antimutagens.
Author Waters, M. D. ; Brady, A. L. ; Stack, H. F. ; Brockman, H. E. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC. ;Environmental Health Research and Testing, Inc., Research Triangle Park, NC. ;Illinois State Univ., Normal. Dept. of Biological Sciences.
Publisher 1989
Year Published 1989
Report Number EPA/600/D-89/145;
Stock Number PB90-112806
Additional Subjects Pharmacology ; Antineoplastic agents ; Bioassay ; Salmonella typhimurium ; Carcinogenicity tests ; Mutagenicity tests ; Structure-activity relationship ; DNA damage ; DNA repair
Library Call Number Additional Info Location Last
NTIS  PB90-112806 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 34p
Experimental evidence suggests that chemical mutagenesis and carcinogenesis are related phenomena such that identification of causative agents and protection from exposure might prevent certain human cancers and related diseases. Agents that inhibit the processes of mutagenesis and carcinogenesis, particularly naturally occurring agents, might be expected to exert a primary protective effect. The paper considers the use of short-term bioassays to identify antimutagenic and anticarcinogenic substances and to classify them (cf. Mutation Res. 168 (1986) 47-65) according to the locus of their protective influence, i.e., intracellular or extracellular, and putative mechanism(s) of action. In the extracellular environment, inhibition of formation or uptake of mutagens and inactivation of promutagenic species are examples of antimutagenic mechanisms. Intracellularly, antimutagenic substances have been described as 'scavengers' of radicals, 'blocking agents' (involving at least 3 different mechanisms), and 'suppressing agents'. Additional intracellular mechanisms include alterations in DNA repair processes and/or modification of the genotoxic response to the mutagen/carcinogen.