Record Display for the EPA National Library Catalog


Main Title Evaluation of the Genetic Activity Profiles of 65 Pesticides.
Author Garrett, N. E. ; Stack, H. F. ; Waters, M. D. ;
CORP Author Environmental Health Research and Testing, Inc., Research Triangle Park, NC.;Health Effects Research Lab., Research Triangle Park, NC. Genetic Toxicology Div.
Year Published 1986
Report Number EPA-68-02-4031; EPA/600/J-86/415;
Stock Number PB88-125455
Additional Subjects Pesticides ; Genetics ; Toxicology ; Organic phosphates ; Chemical properties ; Insecticides ; Ecology ; Physiological effects ; Reprints ; Toxic substances ; Health risks ; Oncogenesis ; Mutagenesis
Library Call Number Additional Info Location Last
NTIS  PB88-125455 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 27p
The report focuses on the quantitative profiles of genetic activity produced by 65 pesticides and efforts to classify them according to their genotoxic effects and chemical structures. Three main categories may be distinguished based on the qualitative results: Category 1 pesticides were active in most of the in vitro and in vivo assays employed. These nine compounds include the structurally similar organophosphate insecticides, acephate, demeton, monocrotophos, and trichlorfon; the phthalimid fungicide analogues, captan and folpet; and the thiocarbamate herbicide analogues, dialiate, sulfallate and triallate. The 26 Category 2 compounds demonstrated fewer positive results and may be subdivided into two parts, one of which contains 12 halogenated aromatic or heterocyclic ring compounds, including the phenoxy herbicides, 2,4-D, 2,4-DB, and 2,4,5-T. The remaining part of Category 2 (14 compounds) consists of structurally similar organophosphate insecticides, azinphos-methyl, crotoxyphos, disulfoton, methyl parathion; three similar ethylenebisdithiocarbamate fungicides, maneb, mancozeb, and zineb; three similar pyrethroid insecticides, allethrin, chrysanthemic acid, and ethy chrysanthemate; and four structurally diverse compounds, cacodylic acid, dinoseb, sec-butylamine and benomyl. The third category of 30 pesticides gave negative results in all tests and represents structurally diverse compounds. Using the computerized profile matching methodology, from 2080 possible pairwise chemical combinations of the 65 pesticides, 20 statistically significant pairs were selected. (Copyright (c) 1986 Elsevier Science Publication B.V.)