|Reactions of Hypochlorite and Organic N-Chloramines in Stomach Fluid.
Scully, F. E. ;
Mazina, K. ;
Sonenshine, D. E. ;
Daniel, F. B. ;
|Old Dominion Univ., Norfolk, VA.;Health Effects Research Lab., Research Triangle Park, NC.
Chemical reactions ;
Hypochlorus acid ;
Drinking water ;
Amino nitrogen compounds ;
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Over the past ten years it has been recognized that chlorine, used to disinfect drinking water, reacts with trace organic compounds dissolved in natural waters to produce by-products which may have adverse health effects in humans. However, little attention has been given to the possible reactions of hypochlorous acid which may take place in the organic-rich medium of the stomach on ingestion of chlorinated drinking water. The average person's daily diet includes a minimum of 30 to 45 grams of protein. Through the action of digestive enzymes in the stomach proteins are broken down into peptones, large polypeptides, and about 15% amino acids. Therefore, a variety of amino nitrogen compounds are available substrates for reaction with aqueous hypochlorous acid in the stomach. It was the objective of the study described here to examine the possibility that organic N-chloramines could be formed on ingestion of hypochlorous acid and to determine whether these compounds could be absorbed into the bloodstream for circulation to other parts of the body.