Record Display for the EPA National Library Catalog


OLS Field Name OLS Field Data
Main Title Manganese Chloride Enhances Murine Cell-Mediated Cytotoxicity: Effects on Natural Killer Cells.
Author Smialowicz, R. J. ; Rogers, R. R. ; Riddle, M. M. ; Luebke, R. W. ; Rowe, D. G. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC.
Year Published 1984
Report Number EPA/600/J-84/076;
Stock Number PB84-238666
Additional Subjects Environmental surveys ; In vitro analysis ; Bioassay ; Manganese chloride ; Antineoplastic agents ; Laboratory animals ; Mice ; Parenteral infusions ; Dosage ; Dose rate ; Pathology ; Toxicity ; Cells(Biology) ; Immunology ; Reprints ; Natural killer cells
Library Call Number Additional Info Location Last
NTIS  PB84-238666 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. 06/23/1988
Collation 26p
Natural killer (NK) cell activity of mice given a single injection of manganese chloride (MnCl2) was significantly enhanced as measured in a 4-hr in vitro 51Cr release assay. Enhanced activity persisted for several days after injection. This cytotoxic activity was associated with nonadherent spleen cells and was completely eliminated by injecting MnCl2-treated mice with anti-asialo GM1 serum. Manganese chloride enhancement of NK cell activity appeared to be mediated by interferon (IFN). Low levels of IFN were detected in the serum of mice as early as 4 hr after MnCl2 injection. Rabbit anti-mouse IFN alpha, beta but not anti-mouse IFN gamma completely eliminated the MnCl2-enhanced NK cell activity in the spleens of mice. The observed enhancement of NK cell activity by MnCl2 is similar to that reported for more complex molecules that act by inducing IFN production.