Record Display for the EPA National Library Catalog


OLS Field Name OLS Field Data
Main Title Immunologic Effects of Perinatal Exposure of Rats to Dioctyltin Dichloride.
Author Smialowicz, S. J. ; Riddle, M. M. ; Rogers, R. R. ; Rowe, D. G. ; Luebke, R. W. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC. Perinatal Toxicology Branch. ;Northrop Services, Inc./Environmental Sciences, Research Triangle Park, NC.
Publisher c1988
Year Published 1988
Report Number EPA/600/J-88/475;
Stock Number PB90-135377
Additional Subjects Immunology ; Toxicology ; Exposure ; Tables(Data) ; Body weight ; Reprints ; Maternal-fetal exchange ; Dictyltin dichloride ; Organ weight ; Natural killer cells ; Gestation ; Lymphoid tissue
Library Call Number Additional Info Location Last
NTIS  PB90-135377 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. 03/10/1990
Collation 22p
Studies were conducted to determine the period of immune system development which was most sensitive to perturbation by the known immunotoxicant di-n-octyltin dichloride (DOTC). Fischer 344 rats were exposed prenatally, both pre- and postnatally or postnatally to DOTC by oral gavage of pregnant and/or lactating females. At various ages, ranging from 3 to 16 weeks of age, offspring were examined for a number of immune functions. These included: body and lymphoid organ weights; lymphoproliferative responses to B and T cell mitogens; natural killer cell activity; and primary antibody response to sheep erythrocytes. Prenatal (day 10-20 of gestation), pre- and postnatal (day 11-20 of gestation and 2-11 days of age), or postnatal (2-13 days of age) oral dosing of dams to 20-50 mg/kg DOTC resulted in no consistent alteration in immune function in offspring. These results suggest that direct dosing of pups during early postnatal life may be the most effective means of inducing immunosuppression with DOTC during immune system development. The results also provide direct evidence for the greater sensitivity of the developing immune system compared with the fully developed immune system for a known immunotoxicant. (Copyright (c) 1988 Hemisphere Publishing Corporation.)