Record Display for the EPA National Library Catalog


OLS Field Name OLS Field Data
Main Title Evaluation of the Immunotoxic Potential of Chlordecone with Comparison to Cyclophosphamide.
Author Smialowicz, R. J. ; Luebke, R. W. ; Riddle, M. M. ; Rogers, R. R. ; Rowe, D. G. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC.
Year Published 1985
Report Number EPA/600/J-85/206;
Stock Number PB86-118866
Additional Subjects Toxicology ; Drugs ; Bioassay ; Rats ; Laboratory animals ; Dosage ; Diets ; Ingestion(Biology) ; Reprints ; Immunotoxicology ; Chlordecone ; Cyclophosphamide
Library Call Number Additional Info Location Last
NTIS  PB86-118866 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. 06/21/1988
Collation 16p
The immunotoxic potential of chlordecone was evaluated in male Fischer 344 rats following 10 days of dosing by oral gavage. These results were compared with a comparable dosing regimen with the known immunosuppressive drug cyclophosphamide. Significant changes in the immune parameters examined, which included spleen and thymus to body weight ratios, mitogen responsiveness to the lymphocyte mitogen conconavalin A and natural killer (NK) cell activity against allogeneic W/Fu-Gl rat lymphoma target cells and xenogeneic YAC-1 mouse lymphoma target cells were observed only at the highest dosage (10 mg/kg/day). A significant decrement in body weight also occurred at this dosage which suggests that the observed changes in the immune parameters measured were most likely due to the overt toxicity of chlordecone at this dosage. Rats dosed over 10 days by oral gavage with cyclophosphamide showed significant decreases in spleen and thymus to body weight ratios at a dosage as low as 1.5 mg/kg/day.