Record Display for the EPA National Library Catalog


Main Title Value of Multiple Endpoint Data in Reproductive Toxicology: Revelations in the Rat.
Author Perreault, S. D. ; Linder, R. E. ; Strader, L. F. ; Slott, V. L. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC.
Year Published 1988
Report Number EPA/600/D-88/135;
Stock Number PB88-225024
Additional Subjects Toxicology ; Reproductive(Biology) ; Males ; Rats ; Laboratory animals ; Exposure ;
Library Call Number Additional Info Location Last
NTIS  PB88-225024 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 36p
To explore the relationship between sperm measures and reproductive success in the laboratory rat, results of several male reproductive toxicology studies containing both fertility and multiple endpoint data are reviewed. Comparisons are made between subchronic and acute exposure studies, stressing the value of multiple endpoint data for each approach. In addition, the choice of endpoints in male reproductive toxicology is discussed with emphasis on those endpoints that are still evolving. The authors conclude that sperm measures are far more sensitive indicators of reproductive organ impairment than is fertility, and that evaluation of multiple endpoints in acute studies is a key step in determining mechanisms of toxicant action that are critical for interspecies risk extrapolation.