Main Title |
Value of Multiple Endpoint Data in Reproductive Toxicology: Revelations in the Rat. |
Author |
Perreault, S. D. ;
Linder, R. E. ;
Strader, L. F. ;
Slott, V. L. ;
|
CORP Author |
Health Effects Research Lab., Research Triangle Park, NC. |
Year Published |
1988 |
Report Number |
EPA/600/D-88/135; |
Stock Number |
PB88-225024 |
Additional Subjects |
Toxicology ;
Reproductive(Biology) ;
Males ;
Rats ;
Laboratory animals ;
Exposure ;
|
Holdings |
Library |
Call Number |
Additional Info |
Location |
Last Modified |
Checkout Status |
NTIS |
PB88-225024 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
Collation |
36p |
Abstract |
To explore the relationship between sperm measures and reproductive success in the laboratory rat, results of several male reproductive toxicology studies containing both fertility and multiple endpoint data are reviewed. Comparisons are made between subchronic and acute exposure studies, stressing the value of multiple endpoint data for each approach. In addition, the choice of endpoints in male reproductive toxicology is discussed with emphasis on those endpoints that are still evolving. The authors conclude that sperm measures are far more sensitive indicators of reproductive organ impairment than is fertility, and that evaluation of multiple endpoints in acute studies is a key step in determining mechanisms of toxicant action that are critical for interspecies risk extrapolation. |