||Genes for Tumor Markers are Clustered with Cellular Proto-Oncogenes on Human Chromosomes.
Hozier, J. C. ;
Mass, M. J. ;
Siegfried, J. M. ;
||Florida Inst. of Tech., Melbourne. ;Environmental Health Research and Testing, Inc., Research Triangle Park, NC.;Health Effects Research Lab., Research Triangle Park, NC.
Malignant neoplasms ;
||Some EPA libraries have a fiche copy filed under the call number shown.
The relative mapping positions of genes for polypeptides expressed abnormally in tumors (tumor markers) and cellular proto-oncogenes were analyzed and a remarkable degree of co-mapping of tumor marker genes with oncogenes in the human karyotype were found. It is proposed that aberrant expression of marker genes in tumors may be related to their proximity in the human genome to oncogenes expressed during the development of malignancy. Ways to test this hypothesis of concerted abnormal gene expression in mammalian tumor cells are suggested. (Copyright (c) 1987 Elsevier Scientific Publishers Ireland Ltd.)