Record Display for the EPA National Library Catalog


Main Title Genes for Tumor Markers are Clustered with Cellular Proto-Oncogenes on Human Chromosomes.
Author Hozier, J. C. ; Mass, M. J. ; Siegfried, J. M. ;
CORP Author Florida Inst. of Tech., Melbourne. ;Environmental Health Research and Testing, Inc., Research Triangle Park, NC.;Health Effects Research Lab., Research Triangle Park, NC.
Year Published 1987
Report Number EPA-R-8117730-11; EPA/600/J-87/255;
Stock Number PB88-182373
Additional Subjects Malignant neoplasms ; Genes ; Mapping ; Peptides ; Cells(Biology) ; Markers ; Abnormalities ; Hypothesis ; Tests ; Analysis ; Chromosomes ; Reprints ; Oncogenes ; Karyotyping
Library Call Number Additional Info Location Last
NTIS  PB88-182373 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 13p
The relative mapping positions of genes for polypeptides expressed abnormally in tumors (tumor markers) and cellular proto-oncogenes were analyzed and a remarkable degree of co-mapping of tumor marker genes with oncogenes in the human karyotype were found. It is proposed that aberrant expression of marker genes in tumors may be related to their proximity in the human genome to oncogenes expressed during the development of malignancy. Ways to test this hypothesis of concerted abnormal gene expression in mammalian tumor cells are suggested. (Copyright (c) 1987 Elsevier Scientific Publishers Ireland Ltd.)