||Immunotoxicological Investigations in the Mouse: General Approach and Methods.
White, K. L. ;
Sanders, V. M. ;
Barnes, D. W. ;
Shopp, G. M. ;
Munson, A. E. ;
||Medical Coll. of Virginia, Richmond. Dept. of Pharmacology and Toxicology. ;East Carolina Univ., Greenville, NC.;Health Effects Research Lab., Research Triangle Park, NC.
Laboratory animals ;
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The adverse effects of chemicals on the lymphoreticular system have generated considerable toxicological interest. In the series of papers, the effects of selected environmentally relevant compounds are reported. The first paper describes the methods and general approach used in judging a chemical's potential risk to the immune system. Risk evaluation was approached utilizing acute, 14- and 90-day studies. Both sexes of the CD-1 random-bred mouse were employed. The immune system was evaluated against a background of more standard toxicological parameters, which included fluid consumption, body and organ weights, hematology, serum and liver chemistries, hepatic microsomal enzyme activities and blood coagulation. Bone marrow status was evaluated by assessing DNA synthesis.