| Main Title |
Hepatocarcinogenicity of Benzo(a)Pyrene to Rainbow Trout By Dietary Exposure and Intraperitoneal Injection. |
| Author |
Hendricks, J. D. ;
Meyers, T. R. ;
Shelton, D. W. ;
Casteel, J. L. ;
Bailey, G. S. ;
|
| CORP Author |
Oregon State Univ., Corvallis. Dept. of Food Science and Technology. ;Oregon State Univ., Corvallis. Agricultural Experiment Station.;Environmental Research Lab., Gulf Breeze, FL. |
| Year Published |
1985 |
| Report Number |
EPA/600/J-85/053; |
| Stock Number |
PB85-210110 |
| Additional Subjects |
Pyrenes ;
Trout ;
Carcinogens ;
Diets ;
Benzene ;
Aromatic polycyclic hydrocarbons ;
Liver ;
Neoplasms ;
Histology ;
Tolerances(Physiology) ;
Growth ;
Mortality ;
Enzymes ;
Reprints ;
Salmo gairdneri ;
BP ;
Pyrene/benzo
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
PB85-210110 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
14p |
| Abstract |
The influence of benzo(a)pyrene on the induction of certain enzymes within the hepataic mixed-function oxidase (MFO) system and its potential carcinogenicity were examined in rainbow trout (Salmo gairdneri). Twelve months after BP exposure was initiated, 15% of the BP-fed fish had histologically confirmed neoplasms of the liver. After 18 months the incidence increased to 25%. No evidence of neoplasia was observed in control fish. These results indicate that BP is a potent inducer of selected hepatic MFO enzymes and establish, for the first time, the hepatocarcinogenicity of BP in an aquatic species. |
