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Main Title Ontogeny of the Acoustic Startle Response and Sensitization to Background Noise in the Rat (Journal Version).
Author Sheets, L. P. ; Dean, K. F. ; Reiter, L. W. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC.
Publisher 1988
Year Published 1988
Report Number EPA/600/J-88/259;
Stock Number PB89-143739
Additional Subjects Noise(Sound) ; Reflexes ; Background noise ; Pseudoconditioning ; Laboratory animals ; Rats ; Stress(Physiology) ; Experimental design ; Reprints ; Acoustic startle response ; Ontogenesis
Library Call Number Additional Info Location Last
NTIS  PB89-143739 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 10p
The purpose of the study was to characterize the ontogeny of the acoustic startle response (ASR), and response sensitization to background noise, in preweanling rats. With constant low-level (45 dB) background noise, response latency decreased steadily with age, whereas, both response incidence and amplitude increased non-monotonically with age. Two approaches were used to examine the ontogeny of sensitization to background noise: the first compared the ASR of animals tested at 75 dB background noise to ones tested at 45 dB; the second compared the ASR of animals tested at 3 background levels (30 dB range) within the test session. In each instance, sensitization was first evident at 16 days of age. Results indicate that daily test experience does not alter ASR amplitude, latency, incidence or the development of sensitization.