||Toxicity of Guthion (Trade Name) and Guthion (Trade Name) 2S to 'Xenopus laevis' Embryos.
Schuytema, G. S. ;
Nebeker, A. V. ;
Griffis, W. L. ;
||Corvallis Environmental Research Lab., OR.
Water pollution effects(Animals) ;
Dose-response relationships ;
Lethal dosage ;
Xenopus laevis ;
FETAX(Frog Embryo Teratogenesis Assay-Xenopus)
||Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy.
Differences in sensitivity to waterborne contaminants between wildlife species have prompted investigations on the sensitivity of amphibiams to potentially hazardous environmental chemicals. The development of Xenopus laevis (African clawed frog) embryos exposed to the pesticide Guthion(Trademark) (technical grade) and Guthion(Trademark) 2S (commercial formulation) was evaluated in modified Frog Embryo Teratogenesis Assay--Xenopus (FETAX) tests. The embryos were exposed to five or six increasing concentrations of pesticide in 10- and 100-ml exposure volumes of test solution for 96 h. Embryos exposed to 10-ml volumes of Guthion exhibited increased mortality, increased deformation, and decreased size as compared to those exposed in 100-ml volumes. LC50s for embryos exposed in the 10-ml Guthion tests ranged from 6.1 to 6.3 mg/L as compared to 10.6 to 11.9 mg/L for those in the 100-ml tests.