Record Display for the EPA National Library Catalog


Main Title Induction by Chloroform of Two Forms of Ornithine Decarboxylase in Rat Liver.
Author Pereira, M. A. ; Savage, Jr., R. E. ; Guion, C. ;
CORP Author Health Effects Research Lab., Cincinnati, OH.
Year Published 1983
Report Number EPA/600/J-83/235;
Stock Number PB84-245679
Additional Subjects Chloroform ; Toxicology ; Biochemistry ; Biosynthesis ; Environmental surveys ; Laboratory animals ; Rats ; Liver ; Neoplasms ; Reprints ; Ornithine decarboxylase
Library Call Number Additional Info Location Last
NTIS  PB84-245679 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 6p
Ornithine decarboxylase (ODC) in rat liver was separated into two species by DEAE - Sepharose CL-6B column chromatography. The activity of both species of ODC was increased at least 20 fold by chloroform treatment of the rats. The major species, peak A contained 75% of the ODC activity and possessed a half-life of 11 mins. The second species, peak B, accounted for twenty-five percent of the activity and possessed a half-life of 50 mins. The long lived species of ODC activity induced in rat liver by chloroform has not been previously reported and might be related to the prolonged induction of ODC activity by chloroform and to tumor promotion and growth.