Record Display for the EPA National Library Catalog


OLS Field Name OLS Field Data
Main Title Health assessment document for acrylonitrile /
Author Neal, Michael W. ; Basu, Dipak K. ; Sugatt, Richard H. ; Hsu, Robert S. ; Santodonato, Joseph
Other Authors
Author Title of a Work
Neal, M. W.
CORP Author United States. Environmental Protection Agency. Office of Research and Development.; Syracuse Univ. Research Corp., NY.; Environmental Protection Agency, Research Triangle Park, NC.
Publisher U.S. Environmental Protection Agency, Office of Research and Development,
Year Published 1982
Report Number EPA-600-8-82-007; SRC-TR-81-596; EPA-68-02-3277; PB83129593
Stock Number PB83-129593
OCLC Number 10190184
Subjects Environmental health. ; Acrylonitrile--Toxicology. ; Carcinogens.
Additional Subjects Environmental health ; Acrylonitrile--Toxicology ; Carcinogens ; Acrylonitriles ; Physical properties ; Chemical properties ; Sampling ; Sources ; Residues ; Transport ; Distribution ; Exposure ; Concentration(Composition) ; Humans ; Laboratory animals ; Air quality ; Analytical methods ; Biological effects ; Toxic substances
Internet Access
Description Access URL
Library Call Number Additional Info Location Last
EHAM  EPA-600-8-82-007 Region 1 Library/Boston,MA 05/25/2016
EIAD  EPA-600/8-82-007 Region 2 Library/New York,NY 03/14/1998 DISPERSAL
EKBD  EPA-600/8-82-007 Research Triangle Park Library/RTP, NC 03/19/2004
ESAD  EPA 600-8-82-007 Region 10 Library/Seattle,WA 03/23/2010
NTIS  PB83-129593 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. 01/01/1988
Collation 1 volume (various pagings) ; 28 cm
Acrylonitrile is readily absorbed in animals following ingestion or inhalation, while dermal absorption is poor (1%) compared to that of the lungs. Acrylonitrile is metabolized to cyanide, which is transformed to thiocyanic acid and by cyanoethylation of sulfhydryl groups to S-(2 cyanoethyl) cysteine, followed by elimination of these metabolites in the urine. Symptoms of intoxication in humans include eye and nose irritation, weakness, labored breathing, dizziness, impaired judgement, cyanosis, nausea and convulsions. Similar symptoms have been observed in animals, including death. In experimental animals, there is considerable species variation in susceptibility to acrylonitrile intoxication; the guinea pig is the most resistant and the dog the most sensitive. Many of the pathological changes observed in rats under chronic exposure conditions are believed to be treatment related.
"Draft. Do not cite or quote." "EPA-600/8-82-007." "November 1982." Includes bibliographical references.