Record Display for the EPA National Library Catalog


Main Title Microbial Degradation of Synthetic Chlorinated Compounds: Evolutionary Implications (Chapter 8).
Author Rothmel, R. K. ; Haugland, R. A. ; Sangodkar, U. M. X. ; Coco, W. M. ; Ahakrabarty, A. M. ;
CORP Author Illinois Univ. at the Medical Center, Chicago. Dept. of Microbiology and Immunology.;Environmental Protection Agency, Cincinnati, OH. Risk Reduction Engineering Lab.
Publisher 1990
Year Published 1990
Report Number EPA-R-812911; EPA/600/A-93/132;
Stock Number PB93-204139
Additional Subjects Microorganisms ; Biodeterioration ; Chlorine organic compounds ; Public health ; Synthesis(Chemistry) ; Herbicides ; Solvents ; Refrigerants ; Selection ; Carbon ; Energy sources ; Genes ; Bacteria ; Tests ; Evolution(Development) ; Test methods ; Enzymes ; D 2-4 herbicide ; T 2-4-5 herbicide ; Synthetic chlorinated compounds ; Pseudomonas cepacia ; Genetic engineering
Library Call Number Additional Info Location Last
NTIS  PB93-204139 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 19p
Environmental release of synthetic chlorinated compounds in the form of herbicides/pesticides, solvents, refrigerants, etc., has created major concerns with regard to their effects on human health because of the persistence of many such compounds. The persistence of these compounds is a result of the inability of natural microorganisms to utilize them as a sole source of carbon and energy. Many microorganisms can utilize simple chlorinated compounds such as 3-chlorobenzoate (3Cba) or 2,4-dichlorophenoxyacetate (2,4-D) as their sole carbon source but cannot utilize higher chlorinated forms such as 2,4,5-trichlorophenoxy acetic acid (2,4,5-T) and others. Under strong selection in a chemostat with 2,4,5-T as the only major source of carbon (directed evolution), it has been possible to isolate a strain of Pseudomonas cepacia AC1100 that can utilize 2,4,5-T as its sole source of carbon and energy.