Record Display for the EPA National Library Catalog

RECORD NUMBER: 3 OF 12

OLS Field Name OLS Field Data
Main Title Evaluation of the Mutagenic Potentials of Platinum Compounds.
Author Sandhu, Shahbeg ;
CORP Author North Carolina Central Univ., Durham. Dept. of Biology.;Health Effects Research Lab., Research Triangle Park, NC.
Year Published 1979
Report Number EPA-R-803299; EPA-600/1-79-033;
Stock Number PB81-228181
Additional Subjects Mutagens ; Platinum inorganic compounds ; Environmental surveys ; Toxicology ; Metals ; Evaluation ; Mice ; Bioassay ; Mutagenesis ; Cell lines ; Toxic substances ; Platinum diaminodichloride ; Platinum diaminodinitrite ; Platinum dichloride ; Platinum tetrachloride
Holdings
Library Call Number Additional Info Location Last
Modified
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Status
NTIS  PB81-228181 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. 06/23/1988
Collation 41p
Abstract
Five platinum compounds, cis-platinum diaminodichloride (cis-PDD), trans-platinum diaminodichloride (trans-PDD), platinum diaminodinitrite, platinum dichloride (PtCl2), and platinum tetrachloride (PtCl4) were evaluated for their mutagenic activity at the thymidine kinase locus in the mouse lymphoma cells line L5178Y. Three of these compounds, i.e., cis-PDD, trans-PDD and PtCl4 yielded significantly higher mutagenic frequencies as compared to the control. Two platinum compounds, i.e., cis-PDD and PtCl4, were also judged to be mutagenic on the basis of results obtained in the Phaseolus mungo plant test system.