Record Display for the EPA National Library Catalog


Main Title Toxicology of 1,1,2-Trichloroethane in the Mouse.
Author White, K. L. ; Sanders, V. M. ; Barnes, D. W. ; Shopp, G. M. ; Munson, A. E. ;
CORP Author Medical Coll. of Virginia, Richmond. Dept. of Pharmacology and Toxicology. ;East Carolina Univ., Greenville, NC.;Health Effects Research Lab., Research Triangle Park, NC.
Year Published 1985
Report Number EPA-R-806481; EPA/600/J-85/415;
Stock Number PB86-214855
Additional Subjects Toxicology ; Bioassay ; Mice ; Laboratory animals ; Lethal dosage ; Liver ; Reprints ; Ethane/trichloro
Library Call Number Additional Info Location Last
NTIS  PB86-214855 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 25p
1,1,2-Trichloroethane (TCE) was administered to male and female CD-1 mice to evaluate its effect on standard toxicological parameters. Following determination of the acute LD50 (378 mg/kg in males and 491 mg/kg in females), and a 14-day range-finding study, a 90-day drinking water study was performed in which the doses consumed were 4.4, 46, and 305 mg/kg for males and 3.9, 44, and 384 mg/kg for females. The liver was a target of TCE toxicity in both sexes as demonstrated by dose-dependent alterations in hepatic microsomal enzyme activities and serum enzyme levels. The erythroid element of the female mice was also affected, as indicated by significantly decreased hematocrit and hemoglobin levels.