This document summarizes current scientific information regarding the health and environmental effects of epichlorohydrin. The observed effects, as presented herein, constitute the health basis from which the U.S. Environmental Protection Agency will make a decision whether to list and to regulate epichlorohydrin as a hazardous air pollutant under the Clean Air Act. Specifically, this document discusses the following topics: physical and chemical properties of epichlorohydrin; environmental occurrence; metabolism, toxicology, and climination; and factors most relevant to assessing quantitative health risks.

Dynamac Corporation prepared the chapters on physical and chemical properties, sampling, analysis, and toxicity data. "Do not cite or quote"--Cover. "Noticee, this document is a preliminary draft. It has not been formally released by EPA and should not at this stage be construed to represent Agency policy. It is being circulated for comment on its tecnical accuracy and policy implications." "EPA/600-8-83-032a." October 1983." Includes bibliographical references (pages R-1-R-14).

3. Background information -- 3.1 Physical and chemical properties -- 3.2 Analytical methodology -- 3.3 Production, use, and releases to the environment -- 3.4 Environmental transport and fate -- 4. Compound distribution and related pharmacokinetics in humans and animals -- 4.1 Routes of exposure and absorption -- 4.2 Distribution -- 4.3 Metabolite identification and pathways -- 4.4 Excretion -- 5. Effects on humans -- 5.1 Epidemiologic studies -- 5.2 Effects on the nervous system -- 5.3 Effects on blood and hematopoietic tissue -- 5.4 Effects on the liver -- 5.5 Effects on the skin -- 5.6 Effects on male fertility -- 6. Animal toxicology -- 6.1 Species sensitivity -- 6.2 Effects on the liver, kidneys, and lungs -- 6.3 Behavorial toxicity and central nervous system effects -- 6.4 Other tissues or organs -- 7. Carcinogenicity, mutagenicity, and reproductive and teratogenic effects -- 8. Synergism and antagonism at the physiological level -- 9. Ecosystem considerations -- 9.1 Effects on microorganisms and plants -- 9.2 Bioconcentration, bioaccumulation, and biomagnification -- 9.3 Effects on aquatic animals -- 10. Regulations and standards -- 10.1 Occupational standards -- 10.2 Food tolerances -- 10.3 Transportation regulations -- 10.4 Water regulations -- 10.5 Solid waste regulations.