Record Display for the EPA National Library Catalog


OLS Field Name OLS Field Data
Main Title Functional Evidence of Persistent Airway Obstruction in Rats Following a Two-Hour Inhalation Exposure to Methyl Isocyanate.
Author Stevens, M. A. ; Fitzgerald, S. ; Menache, M. G. ; Costa, D. L. ; Bucher, J. R. ;
CORP Author Northrop Services, Inc./Environmental Sciences, Research Triangle Park, NC. ;National Toxicology Program, Research Triangle Park, NC.;Health Effects Research Lab., Research Triangle Park, NC.
Year Published 1987
Report Number EPA-68-02-4032; EPA/600/J-87/369;
Stock Number PB88-234851
Additional Subjects Toxicity ; Respiration ; Lung ; Exposure ; Isocyanates ; Laboratory animals ; Lethal dosage ; Toxicology ; Reprints ; Methyl isocyanate ; Toxic substances ; Isocyanic acid/methyl ester ; Respiratory function tests
Library Call Number Additional Info Location Last
NTIS  PB88-234851 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. 12/29/1988
Collation 8p
Pulmonary function was assessed in male F-344 rats 1, 2, 4, 7 and 13 weeks after a single, 2 hour exposure to 0, 3, 10 or 30 ppm MIC. No significant changes were observed in the 3 ppm rats through 13 weeks. Diffusing capacity (DLco), quasi static lung compliance (Crs) and the homogeneity of ventilation as determined by multibreath nitrogen washout were depressed in the 10 and 30 ppm rats by one week postexposure. No 30 ppm rats survived beyond 1 week. By 13 weeks, the 10 ppm rats had dramatic increases in lung volumes while DLco and lung compliance were only mildly affected. Expiratory times during tidal breathing were increased, and the distribution of ventilated air was severely impaired in the group. Collectively, these results suggest the development and likely progression of a severe obstructive airway lesion with associated gas trapping, and the existence of a pronounced concentration-response relationship between 3 and 10 ppm MIC.