Record Display for the EPA National Library Catalog


OLS Field Name OLS Field Data
Main Title Effect of Nickel and Cadmium Chloride on Autonomic and Behavioral Thermoregulation in Mice.
Author Gordon, C. J. ; Stead, A. G. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC.
Year Published 1986
Report Number EPA/600/J-86/449;
Stock Number PB88-171103
Additional Subjects Toxicology ; Nickel chloride ; Cadmium chloride ; Thermoregulation ; Mice ; Laboratory animals ; Reprints ;
Library Call Number Additional Info Location Last
NTIS  PB88-171103 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. 06/21/1988
Collation 12p
Male BALB/c mice were injected intraperitoneally (i.p.) with nickel chloride (0, 5, 10, and 15 mg/kg) or cadmium chloride (0, 2, 4, and 6 mg/kg) while preferred ambient temperature (Ta) and activity were measured. Both metals caused drastic reductions in preferred Ta and activity within 30 min postinjection. Preferred Ta and activity were depressed for up to 90 min following nickel and cadmium injection. In a second experiment, body temperature was measured 60 min following the injection of nickel or cadmium chloride at a Ta of 20, 30, or 35 C. Nickel and cadmium caused a drastic reduction in body temperature when injected at a Ta of 20 and 30 C but produced either no effect or only a slight elevation in body temperature at a Ta of 35 C. In a third experiment, metabolic rate was measured continuously for 60 min following the i.p. injection of a relatively large dose of nickel (15 mg/kg) or cadmium chloride (6 mg/kg) at a Ta of 20, 30, and 35 C. Both metals caused significant reductions in metabolic rate at Ta's of 20 and 30 C.