Record Display for the EPA National Library Catalog


Main Title Repeated Maternal Separation in the Neonatal Rat: Cellular Mechanisms Contributing to Brain Growth Sparing.
Author Lau, C. ; Cameron, A. M. ; Antolick, L. L. ; Stanton, M. E. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC. ;ManTech Environmental Technology, Inc., Research Triangle Park, NC.
Publisher c1992
Year Published 1992
Report Number EPA/600/J-93/125;
Stock Number PB93-181139
Additional Subjects Newborn animals ; Brain ; Growth ; Rats ; Ornithine decarboxylase ; Graphs(Charts) ; Kidney ; Liver ; Heart ; Body weight ; Organ weight ; Lung ; Proteins ; Deoxyribonucleic acids ; Reprints ; Maternal separation
Library Call Number Additional Info Location Last
NTIS  PB93-181139 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 14p
Separation of neonates from their dam has been shown to evoke acutely a variety of biochemical responses, typified by depression of ornithine decarboxylase (ODC) activity. In the current study where rat pups were removed from their nursing dams for 6 h, ODC activities in the liver, heart, kidney and lung were markedly suppressed, but the enzyme in the brain was not altered during the early postnatal ages. These data suggest that the brain was protected from maternal separation insults, a homeostatic response mediated in part, by an increase of circulating corticosterone and glycogen mobilization fromperipheral tissues, particularly the liver. In addition, the authors examined whether these responses were extended to pups who were subject to repeated episodes of maternal deprivation, and whether the stress paradigm might be associated with corresponding changes of cellular growth and maturation.