Record Display for the EPA National Library Catalog


Main Title Pharmaco-Complexity Non-Linear Phenomena and Drug Product Development / [electronic resource] :
Author Hickey, Anthony J.
Other Authors
Author Title of a Work
Smyth, Hugh D.C.
Publisher Springer US : Imprint: Springer,
Year Published 2011
Call Number RM1-950
ISBN 9781441978561
Subjects Medicine ; Toxicology ; Biotechnology ; Biochemistry
Internet Access
Description Access URL
Edition 1.
Collation VIII, 71p. 9 illus., 2 illus. in color. online resource.
Due to license restrictions, this resource is available to EPA employees and authorized contractors only
Contents Notes
The nature of complexity and relevance to the pharmaceutical sciences -- Phenomena in Physical and Surface Chemistry -- Solid State Pharmaceuticals: Solving Complex Problems in Preformulation and Formulation -- Considerations in monitoring and controlling pharmaceutical manufacturing -- Pharmacokinetics and pharmacodynamics -- Impact of complexity on population Biology -- Conclusion. . The historical approach to the interpretation of physical, chemical and biological phenomena has been to consider relationships with causative factors that can be reduced to linearity allowing simple and direct interpretation. However, it is increasingly evident that there is often more information in the data than linear interpretations allow. The current capacity for computers to assist in identifying non-linear relationships allows greater interpretation of data which illuminates the phenomena allowing the information to be translated into knowledge that can be used wisely to promote various desirable pharmaceutical outcomes. This short volume is intended to stimulate the reader to contemplate research and development areas in which the data might be more accurately interpreted to allow greater understanding and ultimately control of the pharmaceutically complex phenomena.