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RECORD NUMBER: 92 OF 212

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Main Title

Factors Determining the In vitro Response of Rodent Embryos to Teratogens.

Author

Sadler, T. W. ; Warner, C. W. ; Tulis, S. A. ; Smith, M. K. ;

CORP Author

North Carolina Univ. at Chapel Hill. School of Medicine.;Health Effects Research Lab., Research Triangle Park, NC.

Year Published

1985

Report Number

EPA/600/D-85/063;

Stock Number

PB85-218840

Additional Subjects

Toxicology ; Bioassay ; In vitro analysis ; Mice ; Rats ; Embryos ; Laboratory animals ; Cadmium ; Teratogenesis ; Animal models ; Hydroxyurea ; Hydantoin/diphenyl ; Cyclophosphamide

Holdings

Library	Call Number	Additional Info	Location	Last Modified	Checkout Status
NTIS	PB85-218840	Some EPA libraries have a fiche copy filed under the call number shown.		07/26/2022

Collation

20p

Abstract

Four teratogens, with different modes of action and pharmacological properties, were selected and investigated in the embryo culture system. The compounds included hydroxyurea (HU), cadmium (Cd), diphenylhydantoin (DPH), and cyclophosphamide (CPP). The overall goal of the study was to characterize the response of early stage (2-6 somites) mouse and rat embryos to these agents in an effort to test the potential of utilizing the system of whole embryo culture for basic teratological and toxicological investigations and as a screening technique for teratogens. The paper summarizes the results of studies with these 4 compounds.

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