||Response of Human Ciliated Respiratory Epithelium to Brief in vivo Ozone Exposure: An Ultrastructural Study (Journal Version).
Carson, J. L. ;
Collier, A. M. ;
Henshaw, N. G. ;
Smith, C. A. ;
Hu, S. C. ;
||North Carolina Univ. at Chapel Hill.;Health Effects Research Lab., Research Triangle Park, NC.
Respiratory system ;
Electron microscopy ;
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Ciliated nasal epithelium obtained from human volunteers exposed under controlled conditions to 0.4 ppm of ozone for four hours was examined by transmission electron microscopy. These investigations were initiated to evaluate the utility of human ciliated nasal epithelium as a model for the characterization of possible ultrastructural level cytopathic effects induced by short-term, low level in vivo exposure to ozone. Particular attention was given to both the qualitative and quantitative evaluation of ciliated cells in the nasal respiratory epithelium in response to ozone exposure. The results of these investigations indicated that cell structure is generally retained and no appreciable manifestations of injury is evident in human nasal mucosa in response to the regimen of ozone exposure employed during these studies. (Copyright (c) by Academic Press, Inc.)