Record Display for the EPA National Library Catalog

RECORD NUMBER: 28 OF 34

Main Title Response of Human Ciliated Respiratory Epithelium to Brief in vivo Ozone Exposure: An Ultrastructural Study (Journal Version).
Author Carson, J. L. ; Collier, A. M. ; Henshaw, N. G. ; Smith, C. A. ; Hu, S. C. ;
CORP Author North Carolina Univ. at Chapel Hill.;Health Effects Research Lab., Research Triangle Park, NC.
Publisher c1985
Year Published 1985
Report Number EPA-68-02-3404; EPA/600/J-85/534;
Stock Number PB89-105472
Additional Subjects Toxicity ; Ozone ; Epithelium ; Respiratory system ; Cilia ; Humans ; Exposure ; Electron microscopy ; Reprints ; Nasal epithelium
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NTIS  PB89-105472 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 17p
Abstract
Ciliated nasal epithelium obtained from human volunteers exposed under controlled conditions to 0.4 ppm of ozone for four hours was examined by transmission electron microscopy. These investigations were initiated to evaluate the utility of human ciliated nasal epithelium as a model for the characterization of possible ultrastructural level cytopathic effects induced by short-term, low level in vivo exposure to ozone. Particular attention was given to both the qualitative and quantitative evaluation of ciliated cells in the nasal respiratory epithelium in response to ozone exposure. The results of these investigations indicated that cell structure is generally retained and no appreciable manifestations of injury is evident in human nasal mucosa in response to the regimen of ozone exposure employed during these studies. (Copyright (c) by Academic Press, Inc.)