Record Display for the EPA National Library Catalog
RECORD NUMBER: 8 OF 19
|OLS Field Name||OLS Field Data|
|Main Title||Lack of Initiating and/or Promoting Activity of Sodium Malondialdehyde on Sencar Mouse Skin.|
|Author||Fischer, S. M. ; Ogle, S. ; Marnett, L. J. ; Nesnow, S. ; Slaga, T. J. ;|
|CORP Author||Health Effects Research Lab., Research Triangle Park, NC. Experimental Biology Div. ;Oak Ridge National Lab., TN. ;Wayne State Univ., Detroit, MI. Dept. of Chemistry.|
|Additional Subjects||Toxicology ; Mutagens ; Mice ; Skin(Anatomy) ; Reprints ; Carcinogenesis ; Malondialdehyde|
Malondialdehyde (MDA), a lipid peroxidation product, has been implicated in carcinogenesis in part for its reported mutagenic activity. It was of interest therefore, to determine its activity as either a complete carcinogen, a tumor initiator, or a tumor promoter. Using the SENCAR mouse skin model, pure sodium MDA (NaMDA) was found to lack activity in any of these categories. Furthermore, NaMDA was determined to be negative in the Chinese hamster V-79 metabolic cooperation assay for promoters.