Record Display for the EPA National Library Catalog


OLS Field Name OLS Field Data
Main Title Lack of Initiating and/or Promoting Activity of Sodium Malondialdehyde on Sencar Mouse Skin.
Author Fischer, S. M. ; Ogle, S. ; Marnett, L. J. ; Nesnow, S. ; Slaga, T. J. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC. Experimental Biology Div. ;Oak Ridge National Lab., TN. ;Wayne State Univ., Detroit, MI. Dept. of Chemistry.
Year Published 1983
Report Number EPA-600/J-83-166;
Stock Number PB84-170968
Additional Subjects Toxicology ; Mutagens ; Mice ; Skin(Anatomy) ; Reprints ; Carcinogenesis ; Malondialdehyde
Library Call Number Additional Info Location Last
NTIS  PB84-170968 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. 06/23/1988
Collation 8p
Malondialdehyde (MDA), a lipid peroxidation product, has been implicated in carcinogenesis in part for its reported mutagenic activity. It was of interest therefore, to determine its activity as either a complete carcinogen, a tumor initiator, or a tumor promoter. Using the SENCAR mouse skin model, pure sodium MDA (NaMDA) was found to lack activity in any of these categories. Furthermore, NaMDA was determined to be negative in the Chinese hamster V-79 metabolic cooperation assay for promoters.