Record Display for the EPA National Library Catalog


OLS Field Name OLS Field Data
Main Title Initiation, Promotion, and Complete Carcinogenesis by N-Methyl-N'-Nitro-N-Nitrosoguanidine or Ethylnitrosourea in the SENCAR Mouse Skin Tumorigenesis Model.
Author O'Connell, J. F. ; Nesnow, S. ; Slaga, T. J. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC.;Texas Univ. System Cancer Center, Smithville.
Year Published 1987
Report Number EPA/600/J-87/318;
Stock Number PB88-196043
Additional Subjects Nitro compounds ; Carcinogens ; Skin cancer ; Mice ; Neoplasms ; Pharmacology ; Toxicity ; Reprints ; Ethylnitrosourea ; Methylnitronitrosoguanidine ; Skin neoplasms ; Papilloma ; Cocarcinogenesis
Library Call Number Additional Info Location Last
NTIS  PB88-196043 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. 09/04/1988
Collation 12p
Five doses of either N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) or ethylnitrosourea (ENU) were tested as complete carcinogens, tumor initiators and tumor promoters in the SENCAR skin tumorigenesis model. As tumor initiators, MNNG-induced papillomas at all doses tested, while ENU was active from 10-40 micromol. As complete carcinogens, MNNG from doses of 0.5-5.0 micromol and ENU from doses of 10 micromol-40 micromol were potent inducers of both papillomas and carcinomas indicating that these agents are active as both tumor initiators and tumor promoters. (Copyright (c) 1987 Elsevier Scientific Publishers Ireland Ltd.)