Record Display for the EPA National Library Catalog


OLS Field Name OLS Field Data
Main Title Eyeblink Conditioning in the Developing Rat.
Author Stanton, M. E. ; Skelton, R. W. ; Freeman, J. H. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC. ;Victoria Univ. (British Columbia). ;North Carolina Univ. at Chapel Hill.
Publisher c1992
Year Published 1992
Report Number EPA/600/J-92/336;
Stock Number PB92-232982
Additional Subjects Conditioning(Learning) ; Rats ; Acoustic stimulation ; Development ; Nervous system ; Reprints ; Eyeblink
Library Call Number Additional Info Location Last
NTIS  PB92-232982 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. 06/01/1993
Collation 11p
Long-Evans rat pups, 17-18 or 24 days of age, were trained with an eyeblink conditioning (EBC) procedure that has recently been used with adult rats. Pups received 3 sessions of delay conditioning in a single day, at about 4 hour intervals (100 trials/session). Trials involved pairings of an auditory conditioned stimulus (2.8 KHZ, 82 dB tone), and a periocular-shock unconditioned stimulus (US, 100msec, 2 mA), presented 280-msec apart. EBC was observed at both ages, but older pups learned much more rapidly. Subsequent experiments established that the effect is associative (Experiment 2), that age differences in EBC cannot be attributed to differences in the ability to respond or in sensitivity to the US (Experiment 3); and that EBC can be modulated by motivational state (Experiment 4). These results indicate that EBC can be studied in the developing rat. Further use of the preparation could help elucidate the relation between neural development and the ontogeny of learning.