Record Display for the EPA National Library Catalog


Main Title Dominant Lethal Assay of Chlordecone and Its Distribution in the Male Reproductive Tissues of the Rat.
Author Simon, G. S. ; Egle, J. L. ; Dougherty, R. W. ; Borzelleca, J. F. ;
CORP Author Virginia Commonwealth Univ., Richmond. Dept. of Pharmacology and Toxicology.;Health Effects Research Lab., Research Triangle Park, NC.
Year Published 1986
Report Number EPA-R-804290; EPA/600/J-86/168;
Stock Number PB87-117891
Additional Subjects Reproduction(Biology) ; Toxicology ; Rats ; Laboratory animals ; Males ; Tissues(Biology) ; Bioassay ; Reprints ; Chlordecone
Library Call Number Additional Info Location Last
NTIS  PB87-117891 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 11p
Male rats received 3.6 or 11.4 mg/kg/day of chlordecone orally for 5 days. Some statistically significant events were seen in the reproductive data of females mated to males receiving chlordecone. However, these events did not follow a consistent pattern and do not suggest the conclusion that chlordecone causes dominant lethal effects. Male rats received a single oral dose (40 mg/kg) of chlordecone and were killed at 1, 2, 3, 5, 7, 14 or 21 days. Chlordecone was distributed throughout the reproductive tract. The descending order of concentration was seminal vesicular fluid > prostate > vas deferens > seminal vesicle > unwashed sperm > washed sperm. It is concluded that chlordecone is well distributed throughout the reproductive tract of the male rat, appears in the ejaculate, and does not appear to produce dominant lethal effects.