| Main Title |
Naphthalene Toxicity in CD-1 Mice: General Toxicology and Immunotoxicology. |
| Author |
Shopp, G. M. ;
White, K. L. ;
Holsapple, M. P. ;
Barnes, D. W. ;
Duke, S. S. ;
|
| CORP Author |
Medical Coll. of Virginia, Richmond. Dept. of Pharmacology. ;East Carolina Univ., Greenville, NC. School of Medicine.;Health Effects Research Lab., Research Triangle Park, NC. |
| Year Published |
1984 |
| Report Number |
EPA/600/J-84/159; |
| Stock Number |
PB85-146397 |
| Additional Subjects |
Toxicology ;
Environmental surveys ;
Laboratory animals ;
Exposure ;
Metabolism ;
Mutagens ;
Insecticides ;
Dosage ;
Reprints ;
Naphthalene
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
PB85-146397 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
18p |
| Abstract |
The purpose of this study was to evaluate the acute and subchronic toxicity, and effects on immune function, of naphthalene (NAP) in random-bred CD-1 mice. The acute oral LD50 of this compound was 533 and 710 mg/kg in male and female mice, respectively. Fourteen- and ninety-day daily oral gavage studies were conducted. A dose of 1/2 the LD50 for 14 days resulted in decreased body weight and decreased spleen and thymus weight in females and males, respectively. Doses of up to 1/4 the LD50 for 90 days resulted in no dose related natalities or decreases in body weight. A dose dependent decrease in aryl hydrocarbon hydroxylase was seen. The immunological parameters assessed (i.e. humoral immunity, cell-mediated immunity, lymphocyte responsiveness and bone marrow function) were not affected in these subchronic studies. |
