||Tumorigenesis and Genotoxicity of Ethyl Carbamate and Vinyl Carbamate in Rodent Cells.
Allen, J. W. ;
Stoner, G. D. ;
Pereira, M. A. ;
Backer, L. C. ;
Sharief, Y. ;
||Health Effects Research Lab., Research Triangle Park, NC. ;Medical Coll. of Ohio at Toledo. ;Environmental Health Research and Testing, Inc., Research Triangle Park, NC. ;Northrop Services, Inc./Environmental Sciences, Research Triangle Park, NC.
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Vinyl carbamate (VC) is a suspect metabolic intermediate in ethyl carbamate (EC) carcinogenesis. In the present studies, EC and VC were evaluated for their relative abilities to induce adenomas and sister chromatid exchanges (SCEs) in lung cells of A, C3H, and C57BL strain mice. For both endpoints, animals were administered a single intraperitoneal injection of the test chemical. Percent of mice with adenomas and number of adenomas per mouse were compared among the three strains 24 weeks following exposure to EC or VC-induced SCE frequencies declined over a 2-week observation period, again, there was no strain specificity for this effect. VC was also tested for enhancement of SA7 virus transformation of Syrian hamster embryo cells. Significant concentration-dependent increases in cell transformation frequency were observed. (Copyright (c) Cancer Research 46, 4911-4915, October 1986.)