Record Display for the EPA National Library Catalog


OLS Field Name OLS Field Data
Main Title Further Evidence That Dichloromethane Does Not Induce Chromosome Damage.
Author Westbrook-Collins, B. ; Allen, J. W. ; Sharief, Y. ; Campbell, J. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC. Genetic Toxicology Div. ;Environmental Health Research and Testing, Inc., Research Triangle Park, NC.
Publisher c1990
Year Published 1990
Report Number EPA/600/J-90/140;
Stock Number PB91-109785
Additional Subjects Toxicity ; Carcinogens ; Solvents ; Rats ; Bone marrow ; Mice ; In vivo analysis ; In vitro analysis ; Reprints ; Methylene chloride ; Chromosome aberrations ; Mutagenicity tests ; Cultured cells ; Sister chromatid exchange
Library Call Number Additional Info Location Last
NTIS  PB91-109785 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. 03/04/1991
Collation 5p
Dichloromethane (DCM) is a widely used industrial solvent which has been determined to be a carcinogen in rats and mice. In vitro and in vivo analyses of chromosome damage induced by this agent have provided conflicting results. In order to further investigate the clastogenic potential of DCM in vivo, we analyzed SCEs and chromosome aberrations (CAs) in mouse bone marrow cells following intraperitoneal exposures. DCM failed to increase the frequencies of either SCEs or CAs.