||Correlation of Mixed-Function Oxidase Activity with Ultrastructural Changes in the Liver of a Marine Fish.
Schoor, W. Peter ;
Couch, John A. ;
||Environmental Research Lab., Gulf Breeze, FL.
Parenteral infusions ;
Mugil cephalus ;
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Specimens of mullet (Mugil cephalus), a marine fish, were given single doses of 3-methylcholanthrene intraperitoneally and the activity of the microsomal mixed-function oxygenase system in the liver was measured by the metabolism of benzo(a)-pyrene. The enzyme system was found to be inducible with concomitant ultrastructural changes in the hepatocytes. The specific activity and the metabolic profile approximate those of the rat.