Record Display for the EPA National Library Catalog


Main Title Rodent Whole-Embryo Culture as a Teratogen Screening Method (Journal Version).
Author Kitchin, K. T. ; Schmid, B. P. ; Sanyal, M. K. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC. ;Yale Univ., New Haven, CT. School of Medicine.
Publisher c1986
Year Published 1986
Report Number EPA/600/J-86/491;
Stock Number PB89-104863
Additional Subjects Teratogens ; Toxicology ; Drug screening ; Methodology ; Embryo ; Laboratory animals ; Tissue culture ; Fetal development ; Postimplantation phase ; Reprints ;
Library Call Number Additional Info Location Last
NTIS  PB89-104863 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 12p
In vitro rodent whole embryo culture offers a wholistic system in which extremely rapid cell division and specific time-related morphogenic events occur. Because in vitro development so closely parallels that occurring in vivo, the in vitro embryo culture system appears to be particularly relevant in the detection of teratogenic and embryotoxic compounds. Correlation between the in vitro screen and the published results of in vivo embryo toxicology and teratology studies has been very good. There is a high correlation (r=0.97) between the concentration of teratogenic agents which cause adverse effects in vitro and the in vivo teratogenic dose of these compounds.