||Comparison of Animal Infectivity and Excystation as Measures of 'Giardia muris' Cyst Inactivation by Chlorine.
Hoff, J. C. ;
Rice, E. W. ;
Schaefer, F. W. ;
||Environmental Protection Agency, Cincinnati, OH. Water Engineering Research Lab.
In vitro analysis ;
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In the study, in vitro excystation and mouse infectivity were compared as methods for quantitatively determining the viability of Giardia muris cysts before and after exposure to free residual chlorine. The mouse infectivity results show that very few cysts (1-15) constitute an infectious dose. The results of the inactivation studies indicate that in vitro excystation is an adequate indication of cyst animal infectivity and can be used to determine the effects of disinfectants on cyst viability.