Record Display for the EPA National Library Catalog


Main Title Conformational Flexibility of Bleomycin-A2: A Carbon 13 Spin-Lattice Relaxation Time Study.
Author Krishna, N. R. ; Dallas, Jerry L. ; Mooberry, Ed S. ; Sakai, Ted T. ; Allen, Richard C. ;
CORP Author Alabama Univ. in Birmingham.;Health Effects Research Lab., Research Triangle Park, NC.
Year Published 1978
Report Number EPA-R-804916; EPA-600/J-78-191;
Stock Number PB82-154881
Additional Subjects Spin lattice relaxation ; Isotopic labeling ; Reprints ; Molecular conformation ; Bleomycin ; NSC 125066 ; Carbon 13
Library Call Number Additional Info Location Last
NTIS  PB82-154881 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 10p
The extent of segmental motion of the backbone and sidechain carbons of the glycopeptide antibiotic, bleomycin-A(2) in aqueous solution, has been determined from the natural abundance carbon-13 spin-lattice relaxation times T(1) measured at 67.89 MHz. The backbone carbons of the central residues have an average T(1) of 163 msec, corresponding to an isotropic rotational correlation time of 3.9 x 10 to the -10 power sec. The backbone and sidechain carbons exhibit varying degrees of motional freedom. The solution conformation of bleomycin-A(2) is discussed in terms of the conformational flexibility available to these carbons.