||Polychlorinated Biphenyls as Inducers of Hepatic Microsomal Enzymes: Effects of Di-Ortho Substitution.
Parkinson, A. ;
Robertson, L. W. ;
Safe, L. ;
Safe, S. ;
||Guelph Univ. (Ontario).;Environmental Research Lab.-Duluth, MN.
Chlorine organic compounds ;
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All of the 13 possible polychlorinated biphenyl (PCB) isomers and congeners substituted at both para positions, at least two meta positions (but not necessarily on the same ring) and at two ortho positions have been synthesized and tested as rat hepatic microsomal enzyme inducers. The effects of these compounds were evaluated by measuring microsomal benzo(a)pyrene (B(a)P) hydroxylase, 4-chlorobiphenyl (4-CBP) hydroxylase, 4-dimethylaminoantipyrine (DMAP) N-demethylase and NADPH-cytochrome c reductase activities, the cytochrome b5 content and the relative peak intensities and spectral shifts of the carbon monoxide (CO)- and ethylisocyanide (EIC)-difference spectra of ferrocytochrome P-450. The results were compared to the effects of administering phenobarbitone (PB), 3-methylcholanthrene (MC) and PB plus MC (coadministered).