Record Display for the EPA National Library Catalog


OLS Field Name OLS Field Data
Main Title Polychlorinated Biphenyls as Inducers of Hepatic Microsomal Enzymes: Effects of Di-Ortho Substitution.
Author Parkinson, A. ; Robertson, L. W. ; Safe, L. ; Safe, S. ;
CORP Author Guelph Univ. (Ontario).;Environmental Research Lab.-Duluth, MN.
Year Published 1981
Report Number EPA-R-806928; EPA-600/J-81-667;
Stock Number PB84-123868
Additional Subjects Enzymes ; Ribosomes ; Chlorine organic compounds ; Rats ; Liver ; Reprints ; Polychlorinated biphenyls
Library Call Number Additional Info Location Last
NTIS  PB84-123868 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. 06/23/1988
Collation 16p
All of the 13 possible polychlorinated biphenyl (PCB) isomers and congeners substituted at both para positions, at least two meta positions (but not necessarily on the same ring) and at two ortho positions have been synthesized and tested as rat hepatic microsomal enzyme inducers. The effects of these compounds were evaluated by measuring microsomal benzo(a)pyrene (B(a)P) hydroxylase, 4-chlorobiphenyl (4-CBP) hydroxylase, 4-dimethylaminoantipyrine (DMAP) N-demethylase and NADPH-cytochrome c reductase activities, the cytochrome b5 content and the relative peak intensities and spectral shifts of the carbon monoxide (CO)- and ethylisocyanide (EIC)-difference spectra of ferrocytochrome P-450. The results were compared to the effects of administering phenobarbitone (PB), 3-methylcholanthrene (MC) and PB plus MC (coadministered).