| Main Title |
Polychlorinated Biphenyls as Inducers of Hepatic Microsomal Enzymes: Structure-Activity Rules. |
| Author |
Parkinson, A. ;
Robertson, L. ;
Safe, Lorna ;
Safe, S. ;
|
| CORP Author |
Guelph Univ. (Ontario).;Environmental Research Lab.-Duluth, MN. |
| Year Published |
1980 |
| Report Number |
EPA-R-806928; EPA-600/J-80-419; |
| Stock Number |
PB83-243741 |
| Additional Subjects |
Enzymes ;
Ribosomes ;
Molecular structure ;
Laboratory animals ;
In vivo analysis ;
Bioassay ;
Toxicity ;
Public health ;
Chlorine organic compounds ;
Rats ;
Dosage ;
Liver ;
Reprints ;
Polychlorinated biphenyls ;
Toxic substances ;
Chemical shifts(Nuclear magnetic resonance)
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
PB83-243741 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
18p |
| Abstract |
A number of highly purified polychlorinated biphenyl (PCB) isomers and congeners were synthesized and administered to male Wistar rats at dosage levels of 30 and 150 micromol/kg. The effects of this in vivo treatment on the drug-metabolizing enzymes were determined by measuring the microsomal benzo(a)pyrene (B(a)P) hydroxylase, dimethylaminoantipyrine (DMAP) N-demethylase and NADPH-cytochrome c reductase enzyme activities, the cytochrome b sub 5 content and the relative peak intensities of spectral shifts of the reduced microsomal cytochrome P-450:CO and ethylisocyanide (EIC) binding difference spectra. |
