||Genetic Toxicology of Putative Nongenotoxic Carcinogens.
Jackson, M. A. ;
Stack, H. F. ;
Waters, M. D. ;
||Health Effects Research Lab., Research Triangle Park, NC. Genetic Toxicology Div.;Environmental Health Research and Testing, Inc., Research Triangle Park, NC.
Mutagenicity tests ;
Biological assays ;
Organic compounds ;
Chromosomal aberrations ;
Genetic activity profile ;
Gene mutations ;
Putative nongenotoxic carcinogens ;
Short term tests
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The report examines a group of putative nongenotoxic carcinogens that have been cited in the published literature. Using short-term test data from the U.S. Environmental Protection Agency/International Agency for Research on Cancer genetic activity profile (EPA/IARC GAP) database, these agents are classified on the basis of their mutagenicity emphasizing three genetic endpoints: gene mutation, chromosomal aberration and aneuploidy. On the basis of results of short-term tests for these effects, criteria was defined for evidence of mutagenicity (and nonmutagenicity) these criteria were applied in classifying the group of putative nongenotoxic carcinogens. The results from this evaluation based on the EPA/IARC GAP database are presented along with a summary of the short-term test data for each chemical and the relevant carcinogenicity results from the NTP, Gene-Tox and IARC databases. The data clearly demonstrate that many of the putative nongenotoxic carcinogens that have been adequately tested in short-term bioassays induce gene or chromosomal mutations or aneuploidy. (Copyright (c) 1993 Elsevier Science Publishers B.V.)